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Two new microcyclamides from a water bloom of the cyanobacterium Microcystis sp.

✍ Scribed by Ella Zafrir-Ilan; Shmuel Carmeli

Book ID
104098461
Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
187 KB
Volume
51
Category
Article
ISSN
0040-4039

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✦ Synopsis

a b s t r a c t

Two new thiazole-containing cyclic hexapeptides, microcyclamides MZ602 and MZ568, were isolated from the hydrophilic extract of the cyanobacterium Microcystis sp. The structures of the pure natural products were elucidated using spectroscopic methods including UV, 1D and 2D NMR, and MS techniques. The absolute configuration of the chiral centres of the modified cyclic peptides was determined using Marfey's method for HPLC. The microcyclamides have been evaluated for their cytotoxicity against leukemia cell lines and inhibition of serine proteases.

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Inhibitors of serine proteases from a wa
Inhibitors of serine proteases from a waterbloom of the cyanobacterium Microcystis sp.
✍ Ronny Banker; Shmuel Carmeli πŸ“‚ Article πŸ“… 1999 πŸ› Elsevier Science 🌐 French βš– 592 KB

Three new protease inhibitors, micropeptins SF909 (1) and SF995 (2) and microcin SF608 (3), were isolated from the hydrophilic extract ofa microcystis sp. waterbloom. The planar structure of compounds !-3 was determined by homonuclear and inverse-heteronuelear 2D-NMR techniques as well as high-resol