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Two New Meroterpenes from the Mangrove Endophytic Fungus Aspergillus sp. 085241B

✍ Scribed by Yong-Xiang Song; Li-Tao Qiao; Jia-Jian Wang; Hua-Ming Zeng; Zhi-Gang She; Cheng-Du Miao; Kui Hong; Yu-Cheng Gu; Lan Liu; Yong-Cheng Lin

Publisher
John Wiley and Sons
Year
2011
Tongue
German
Weight
201 KB
Volume
94
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Two new meroterpenes, ‘acetoxydehydroaustin B’ (1) and ‘1,2‐dihydro‐acetoxydehydroaustin B’ (2) were isolated in the form of a mixed crystal from the mangrove endophytic fungus Aspergillus sp. 085241B. Their structures and absolute configurations were determined by extensive analysis of their spectra and X‐ray diffraction data. In a preliminary bioassay, the mixed crystal did not exhibit activities against cancer cell lines of MDA‐MB‐435, SKBR3, HepG2, HEP3B, PC‐3, and A549, as well as against α‐glucosidase and tyrosinase.

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