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Metabolites from the Mangrove Endophytic Fungus Phomopsis sp. (#zsu-H76)

✍ Scribed by Jianxiang Yang; Fang Xu; Caihuan Huang; Jing Li; Zhigang She; Zhong Pei; Yongcheng Lin

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
132 KB
Volume
2010
Category
Article
ISSN
1434-193X

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✦ Synopsis

Abstract

Three unique metabolites, namely, phomopsis‐H76 A (1), B (2), and C (3), were isolated from the mangrove endophytic fungus Phomopsis sp. (#zsu‐H76). Structures were determined by spectroscopic methods, mainly 1D and 2D NMR spectroscopy. Compound 1–3 are all dimers. Compounds 2 and 3 possesses a pyrano[4,3‐b]pyran‐5(2__H__)‐one ring system that is unprecedented in nature. Primary bioassays showed that 1 accelerated the growth of subintestinal vessel plexus (SIV) branch markedly, whereas 3 showed inhibition of SIV. Compounds 1–3 showed no activity in antibacterial and cytotoxic tests.

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