Two New Indole Alkaloids from Tabernaemontana hystrixSteud. (Apocynaceae)

✍ Scribed by Jucimar J. de Souza; Leda Mathias; Raimundo Braz-Filho; Ivo J. Curcino Vieira

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: German
• Weight: 194 KB
• Volume: 93
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200900208

✦ Synopsis

Abstract

Two new monoterpene indole alkaloids named ibogamine‐7,8‐dione (1) and 12‐methoxyvoachalotine (2), and eight known ones, coronaridine (3), coronaridine hydroxyindolenine (4), 5‐oxocoronaridine (5), 3‐oxocoronaridine hydroxyindolenine (6), 3‐oxocoronaridine (7), vobasine (8), ibogamine (9), and olivacine (10), were isolated from a CH~2~Cl~2~ extract of the root bark from Tabernaemontana hystrix. The structures of the compounds were elucidated on the basis of spectroscopic data analyses, mainly ^1^H‐ and ^13^C‐NMR, including 2D experiments (^1^H,^1^H‐COSY, HMBC, and HMQC).