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Two methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms, schizophrenia and bipolar disorder: An association study

✍ Scribed by Erik G Jönsson; Kristina Larsson; Maria Vares; Thomas Hansen; August G. Wang; Srdjan Djurovic; Kjersti S. Rønningen; Ole A. Andreassen; Ingrid Agartz; Thomas Werge; Lars Terenius; Håkan Hall

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
87 KB
Volume
147B
Category
Article
ISSN
1552-4841

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✦ Synopsis

Abstract

Recent meta‐analyses of the methylenetetrahydrofolate reductase gene (MTHFR) have suggested association between two of its functional single gene polymorphisms (SNPs; C677T and A1298C) and schizophrenia. Studies have also suggested association between MTHFR C677T and A1298C variation and bipolar disorder. In a replication attempt the MTHFR C677T and A1298C SNPs were analyzed in three Scandinavian schizophrenia case‐control samples. In addition, Norwegian patients with bipolar disorder were investigated. There were no statistically significant allele or genotype case‐control differences. The present Scandinavian results do not verify previous associations between the putative functional MTHFR gene polymorphisms and schizophrenia or bipolar disorder. However, when combined with previous studies in meta‐analyses there is still evidence for association between the MTHFR C677T polymorphism and schizophrenia. Additional studies are warranted to shed further light on these relationships. © 2007 Wiley‐Liss, Inc.

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