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Two-dimensional NMR spectroscopy of LL-28249-α, a potent macrolide anthelmintic: 13C, 1H chemical shift assignments and solution conformation

✍ Scribed by S. Rajan; G. W. Stockton

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
538 KB
Volume
27
Category
Article
ISSN
0749-1581

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✦ Synopsis

LL-F28249-a is a potent antiparasitic antibiotic produced by Streptomyees cyaneogriseus ssp. noncyanogenus. Its complete ''C NMR spectral assignment based on two-dimensional doublequantum experiments in a sample at natural isotopic abundance is described. The proton NMR assignments were made from a combination of homonuclear and heteronuclear two-dimensional correlation experiments. Proton-proton scalar couplings, nuclear Overhauser enhancements and molecular mechanics energy minimization calculations are also reported, permitting a comparison of solution conformation with the known x-ray structure adapted from a closely related analogue.

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