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Two-dimensional and deuterium-induced, differential-isotope-shift nuclear magnetic resonance characterization of potassium sucrose octasulfate and sucralfate

✍ Scribed by Gary L. Silvey

Book ID
102409308
Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
395 KB
Volume
81
Category
Article
ISSN
0022-3549

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✦ Synopsis

Two-dimensional and deuterium-induced, differential-isotope-shift NMR measurements have made it possible to assign completely all of the 1H and 13C resonances of potassium sucrose octasulfate (K8SOS) and thereby prove complete sulfation of the sugar moiety during synthesis. In addition, a comparison of the 13C NMR chemical shifts obtained for K8SOS and sucralfate made it possible to demonstrate that the sugar moiety in sucralfate is sucrose octasulfate (SOS8-). Finally, deuterium-induced, differential-isotope-shift and 13C NMR techniques were shown to be useful tools for detecting and characterizing carbon-containing impurities and hydrolysis products in solutions containing SOS8-.

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Deuterium-induced 13C nuclear magnetic resonance isotope shifts and 13C2H couplings for signal assignments and determination of deuteration site in cyclooctanone
✍ Slobodan Milosavljević; Dragoslav Jeremić; Mihailo Lj. Mihailović; Felix W. Wehr 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 158 KB

## Abstract Unambiguous signal assignments in the ^13^C spectra of monodeuterated cyclooctanones derived from the lead tetraacetate or silver oxide/bromine oxidations of the corresponding 1‐monodeutero‐alcohols have been obtained from deuterium‐induced ^13^C isotope shifts and geminal and vicinal ^