TWIST1, A novel androgen-regulated gene, is a target for NKX3-1 in prostate cancer cells
✍ Scribed by Turid Eide, Håkon Ramberg, Carlotta Glackin, Donald Tindall…
- Book ID
- 120685482
- Publisher
- BioMed Central
- Year
- 2013
- Tongue
- English
- Weight
- 294 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1475-2867
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## Abstract In this paper we characterize hPARM‐1, the human ortholog of rat PARM‐1 (prostatic androgen‐repressed message‐1) and demonstrate its role in prostate cancer. Immunofluorescence microscopy and ultrastructural analysis revealed the localization of hPARM‐1 to Golgi, plasma membrane and the
## Abstract Androgen‐regulated genes (ARG) are implicated in normal and neoplastic growth of the prostate. Recently, we reported genomic amplification and/or overexpression of a previously known neurotrophic factor, prosaposin, in androgen‐independent (AI) or metastatic prostate cancer (PCa) cells