Tutorials in Mathematical Biosciences III: Cell Cycle, Proliferation, and Cancer
β Scribed by Baltazar D. Aguda (auth.), Avner Friedman (eds.)
- Book ID
- 127453374
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 7 MB
- Edition
- 1
- Category
- Library
- City
- New York
- ISBN
- 3540324151
- DOI
- 10.1007/11561606
No coin nor oath required. For personal study only.
β¦ Synopsis
This volume introduces some basic mathematical models for cell cycle, proliferation, cancer, and cancer therapy. Chapter 1 gives an overview of the modeling of the cell division cycle. Chapter 2 describes how tumor secretes growth factors to form new blood vessels in its vicinity, which provide it with nutrients it needs in order to grow. Chapter 3 explores the process that enables the tumor to invade the neighboring tissue. Chapter 4 models the interaction between a tumor and the immune system. Chapter 5 is concerned with chemotherapy; it uses concepts from control theory to minimize obstacles arising from drug resistance and from cell cycle dynamics. Finally, Chapter 6 reviews mathematical results for various cancer models.
β¦ Subjects
Physiological, Cellular and Medical Topics
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## Abstract Current treatment of solid tumors is limited by normal tissue tolerance, resulting in a narrow therapeutic index. To increase drug specificity and efficacy and to reduce toxicity in normal tissues, we have developed a polypeptide carrier for a cell cycle inhibitory peptide, which has th