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Turning on the off switch: Regulation of anti-viral T cell responses in the liver by the PD-1/PD-L1 pathway

✍ Scribed by Arash Grakoui; E. John Wherry; Holly L. Hanson; Christopher Walker; Rafi Ahmed


Book ID
116651167
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
205 KB
Volume
45
Category
Article
ISSN
0168-8278

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## Abstract Disease progression in experimental autoimmune encephalomyelitis (EAE) is regulated by programmed death receptor 1 (PD‐1) and its ligands, B7‐H1 (programmed death ligand 1 (PD‐L1)) and B7‐DC (PD‐L2). B7‐H1 and B7‐DC have negative regulatory effects upon binding PD‐1 on activated T cells