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Partial restoration of T-cell function in aged mice by in vitro blockade of the PD-1/ PD-L1 pathway

✍ Scribed by Celine S. Lages; Ian Lewkowich; Alyssa Sproles; Marsha Wills-Karp; Claire Chougnet


Book ID
111199671
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
618 KB
Volume
9
Category
Article
ISSN
1474-9718

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## Abstract Human tumors frequently escape immune destruction, despite the presence of cyototoxic T cells (CTL) recognizing tumor‐associated antigens (TAA). We have previously shown that programmed death ligand‐1 (PD‐L1), a recently identified ligand of the B7 superfamily, is expressed on murine tu