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Tuning the antiproliferative activity of biologically active iron chelators: characterization of the coordination chemistry and biological efficacy of 2-acetylpyridine and 2-benzoylpyridine hydrazone ligands

โœ Scribed by Paul V. Bernhardt; Gregory J. Wilson; Philip C. Sharpe; Danuta S. Kalinowski; Des R. Richardson


Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
546 KB
Volume
13
Category
Article
ISSN
1432-1327

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## Abstract Reaction of a twofold molar excess of bis(2โ€pyridylmethyl)amine DPA with 8ฮฑโ€bromoAc4riboflavin in dry DMF over 24 h affords the 8ฮฑโ€[bis(2โ€pyridylmethyl)amine]โ€__N__โ€Ac~4~riboflavin ligand. This compound can be described as a tweezer in which the flavin moiety acts as a potential electro