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Tuned methods for conjugate addition to a vinyl oxadiazole; synthesis of pharmaceutically important motifs

✍ Scribed by Burns, Alan R.; Kerr, Jennifer H.; Kerr, William J.; Passmore, Joanna; Paterson, Laura C.; Watson, Allan J. B.


Book ID
111644825
Publisher
Royal Society of Chemistry
Year
2010
Tongue
English
Weight
257 KB
Volume
8
Category
Article
ISSN
1477-0520

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Conjugate addition of amines to vinyl su
✍ Heather Tye πŸ“‚ Article πŸ“… 2002 πŸ› Elsevier Science 🌐 French βš– 105 KB

The synthesis of a range of b-amino sulfoximide derivatives is described. The conjugate addition of simple amines or amino acids to N-tosyl phenyl vinyl sulfoximide was achieved in moderate to good yield (41-95%). Electron poor nucleophiles such as tosyl amide or benzyl carbamate were found to be un