Conjugate addition of amines to vinyl sulfoximides: a general method for the synthesis of β-amino sulfoximides

✍ Scribed by Heather Tye

• Book ID: 104252473
• Publisher: Elsevier Science
• Year: 2002
• Tongue: French
• Weight: 105 KB
• Volume: 43
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(02)02326-2

✦ Synopsis

The synthesis of a range of b-amino sulfoximide derivatives is described. The conjugate addition of simple amines or amino acids to N-tosyl phenyl vinyl sulfoximide was achieved in moderate to good yield (41-95%). Electron poor nucleophiles such as tosyl amide or benzyl carbamate were found to be unreactive under analogous conditions.