Tunable Phosphine-Mediated Domino Reaction: Selective Synthesis of 2,3-Dihydrofurans and Biaryls
β Scribed by Xie, Peizhong; Li, Erqing; Zheng, Jie; Li, Xin; Huang, You; Chen, Ruyu
- Book ID
- 118750985
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 345 KB
- Volume
- 355
- Category
- Article
- ISSN
- 1615-4150
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π SIMILAR VOLUMES
## Abstract DFT calculations show, that the bulkiness of the ligand controls the reaction between Ξ±βbenzylideneβΞ²βdicarbonyl compounds (I) and diazoacetate (II) to give either the fiveβ or sevenβmembered products (III)/(V) or (VI)/(VII).
An efficient and mild method for the synthesis of functionalized tricyclic 2,3-dihydrofurans, bicyclic 2,3dihydrofurans, and other tetrasubstituted 2,3-dihydrofurans by domino reaction of 1,3-dicarbonyl compounds and a-bromonitroalkenes with a large substrate scope and excellent diastereoselectivity