Tumour suppression by the human von Hippel-Lindau gene product
β Scribed by Iliopoulos, Othon; Kibel, Adam; Gray, Steven; Kaelin, William G.
- Book ID
- 109929780
- Publisher
- Nature Publishing Group
- Year
- 1995
- Tongue
- English
- Weight
- 720 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1078-8956
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The von Hippel-Lindau gene product (pVHL) interacts with and inhibits the cellular transcription factor elongin. However, the subcellular localization of pVHL has remained uncertain. Naturally occurring pVHL mutants which fail to interact with elongin have been described in patients with VHL disease
A series of 20 capillary haemangioblastomas of the central nervous system was screened for mutations of the von Hippel-Lindau ( VHL) tumour suppressor gene by single strand conformational polymorphism (SSCP) and heteroduplex analysis. Aberrant polymerase chain reaction (PCR) products were detected i