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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

✍ Scribed by Keiichi Kondo; Jeff Klco; Eijiro Nakamura; Mirna Lechpammer; William G Kaelin Jr.


Book ID
114413162
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
490 KB
Volume
1
Category
Article
ISSN
1535-6108

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Induction of the von Hippel-Lindau tumor
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## Abstract Hypoxia–inducible factor (HIF) remains the central focus of oxygen sensing during hypoxia. HIF is a heterodimeric transcription factor consisting of an oxygen‐regulated alpha‐ and a constitutively expressed beta subunit. The von Hippel‐Lindau tumor suppressor (pVHL) is a component of th