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Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5

✍ Scribed by Sergiy Kostenko, Gianina Dumitriu, Ugo Moens

Book ID
119911491
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
693 KB
Volume
7
Category
Article
ISSN
1750-2187

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## Abstract Mitogen‐activated protein (MAP) kinases are typical examples of protein kinases whose enzymatic activity is mainly controlled by activation loop phosphorylation. The classical MAP kinases ERK1/ERK2, JNK, p38 and ERK5 all contain the conserved Thr‐Xxx‐Tyr motif in their activation loop t