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Activation of MK5/PRAK by the atypical MAP kinase ERK3 defines a novel signal transduction pathway

✍ Scribed by Seternes, Ole Morten (author);Mikalsen, Theresa (author);Johansen, Bjarne (author);Michaelsen, Espen (author);Armstrong, Chris G. (author);Morrice, Nick A. (author);Turgeon, Benjamin (author);Meloche, Sylvain (author);Moens, Ugo (author);Keyse, Stephen M. (author)

Book ID: 110030887
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 319 KB
Volume: 23
Category: Article
ISSN: 0261-4189
DOI: 10.1038/sj.emboj.7600489

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## Abstract Mitogen‐activated protein (MAP) kinases are typical examples of protein kinases whose enzymatic activity is mainly controlled by activation loop phosphorylation. The classical MAP kinases ERK1/ERK2, JNK, p38 and ERK5 all contain the conserved Thr‐Xxx‐Tyr motif in their activation loop t