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Tumors of DNA Mismatch Repair-Deficient Hosts Exhibit Dramatic Increases in Genomic Instability

โœ Scribed by Agnes Baross-Francis, Susan E. Andrew, Janice E. Penney and Frank R. Jirik


Book ID
123641506
Publisher
National Academy of Sciences
Year
1998
Tongue
English
Weight
812 KB
Volume
95
Category
Article
ISSN
0027-8424

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Deficiency in DNA mismatch repair increa
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DNA mismatch repair (MMR) is essential for genome stability and inheritance of a mutated MMR gene, most frequently MSH2 or MLH1, results in cancer predisposition known as Lynch syndrome or hereditary nonpolyposis colorectal cancer (HNPCC). Tumors that arise through MMR deficiency show instability at