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Clinical significance of tumor microsatellite instability and immunohistochemistry for mismatch repair deficiency in colorectal cancers

✍ Scribed by Brittany C. Thomas; Stephen N. Thibodeau; Noralane M. Lindor

Book ID: 107535597
Publisher: Current Science Inc.
Year: 2005
Tongue: English
Weight: 647 KB
Volume: 1
Category: Article
ISSN: 1556-3790
DOI: 10.1007/s11888-005-0006-3

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## Abstract Clinical criteria, microsatellite analysis (MSA) and immunohistochemistry (IHC) are important diagnostic tools for identification of hereditary nonpolyposis colorectal cancer (HNPCC) patients who are likely to carry pathogenic germline mutations in mismatch repair genes. Based on MSA an