✦ LIBER ✦

Mismatch repair genes and mononucleotide tracts as mutation targets in colorectal tumors with different degrees of microsatellite instability

✍ Scribed by Percesepe, Antonio; Kristo, Paula; Aaltonen, Lauri A; Ponz de Leon, Maurizio; Chapelle, Albert de la; Peltomäki, Päivi

Book ID: 110061435
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 511 KB
Volume: 17
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1201944

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Microsatellite instability as a predicto

Microsatellite instability as a predictor of a mutation in a DNA mismatch repair gene in familial colorectal cancer

✍ Tao Liu; Siobhan Wahlberg; Eva Burek; Per Lindblom; Carlos Rubio; Annika Lindblo 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 122 KB 👁 2 views

Germline alterations in human DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Mutation analysis of the genes reveals carriers with a high risk of colorectal cancer, who will benefit from surveillance. We wanted to find the best predictive parameter of

Relationship Between Grade of Microsatel

Relationship Between Grade of Microsatellite Instability and Target Genes of Mismatch Repair Pathways in Sporadic Colorectal Carcinoma

✍ Goichi Togo; Yasushi Shiratori; Makoto Okamoto; Yutaka Yamaji; Masayuki Matsumur 📂 Article 📅 2001 🏛 Springer US 🌐 English ⚖ 75 KB

Identification of novel genes with somat

Identification of novel genes with somatic frameshift mutations within coding mononucleotide repeats in colorectal tumors with high microsatellite instability

✍ Uroš Potočnik; Damjan Glavač; Metka Ravnik-Glavač 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 671 KB

## Abstract We have systematically retrieved genes with coding mononucleotide repeats from sequence databases and analyzed them for mutations in tumors with high levels of microsatellite instability (MSI‐H). We found somatic frameshift mutations in 7/13 genes previously not analyzed in MSI‐H tumors

Microsatellite instability and novel mis

Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with Hereditary non-polyposis colorectal cancer

✍ SHENG, Jian Qiu ;CHAN, Tsun Leung ;CHAN, Yee Wai ;HUANG, Ji Sheng ;CHEN, Ji Gui 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB

Aberrant splicing of the ATM gene associ

Aberrant splicing of the ATM gene associated with shortening of the intronic mononucleotide tract in human colon tumor cell lines: A novel mutation target of microsatellite instability

✍ Yosuke Ejima; Lichun Yang; Masao S. Sasaki 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 French ⚖ 181 KB 👁 2 views

Inherited mutations of the ATM gene are responsible for the human autosomal recessive disorder ataxia-telangiectasia (A-T) characterized by pleiotropic clinical manifestations. ATM mutations are also involved in the development of sporadic human cancers such as T-cell prolymphocytic leukemia and B-c

Genomic instability and target gene muta

Genomic instability and target gene mutations in colon cancers with different degrees of allelic shifts

✍ Antonio Percesepe; Monica Pedroni; Elisa Sala; Mirco Menigatti; Francesca Borghi 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 159 KB 👁 1 views

Two grades (high and low) of microsatellite instability (MSI) are known, depending on the number of mutated markers and the amount of allelic shifts. Forty-two colorectal tumors, previously found to have high-degree MSI at dinucleotidic repeat loci, were revisited with BAT26, a mononucleotide marker