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Tumorigenicity of nitropolycyclic aromatic hydrocarbons in the neonatal B6C3F1 mouse bioassay and characterization of ras mutations in liver tumors from treated mice

โœ Scribed by Linda S Von Tungeln; Qingsu Xia; Diogenes Herreno-Saenz; Thomas J Bucci; Robert H Heflich; Peter P Fu

Book ID
117469566
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
116 KB
Volume
146
Category
Article
ISSN
0304-3835

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## Abstract Furan administered by gavage for 2 yr has been reported to induce hepatocellular carcinomas in male and female B6C3F~1~ mice and in male but not female F344 rats. Chronic exposure studies in our laboratory using bioassay conditions showed extensive hepatocellular toxicity and sustained