## Abstract Liver tumors of certain strains of mice frequently contain mutations at codon 61 of the cβHaβ__ras__ gene. In our study, we investigated the significance of these mutations in the carcinogenic process. Male C3H/He mice received a single injection of diethylnitrosamine (DEN) on day 15 af
Spontaneous mutation at codon 61 of the Ha-ras gene in the nascent liver of B6C3F1, C3H/He and C57BL/6 mice
β Scribed by Beth A. Moulds; Jay I. Goodman
- Book ID
- 113194523
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 645 KB
- Volume
- 311
- Category
- Article
- ISSN
- 0027-5107
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ederal Republic of Germany Liver tumors of the B6C3F1 mouse frequently contain mutations at specific sites of codon 61 of the Ha-ras proto-oncogene. To address whether these mutations occur early or late during carcinogenesis, w e analyzed mutations in the Ha-ras gene in small precancerous liver les
The effects of different liver tumor-promoting treatments (i.e., a choline-devoid, methionine-deficient (CMD) diet, phenobarbital (PB), or both) on Ha-ras and raf methylation status and expression were determined in mouse strains with different susceptibilities to liver tumor formation: the relative