✦ LIBER ✦

Tumoral progression of human breast epithelial cells secreting FGF2 AND FGF4

✍ Scribed by Boussad Soutton; Chantal Gamby; Michel Crepin; Richard Hamelin

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 839 KB
Volume: 68
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19961127)68:5<675::aid-ijc19>3.0.co;2-0

No coin nor oath required. For personal study only.

✦ Synopsis

The human breast epithelial cell line HBLIOO synthesizes and secretes FGF2, is able to grow in toft agar but is not tumorigenic in nude mice. Transfection of this cell line with the FGF4 gene led to its tumorigenic conversion in a dose-dependent manner as assessed by growth under serum-free conditions, growth in soft agar and growth as xenografts in nude mice. Clones of

Assay for tumorigenicity

Congenitally athymic Swiss nu/nu (nude) mice (Iffa Credo, L'Arbrcsle, France) werc subcutaneously injected with 1 x lo7 cells (104 cells).

📜 SIMILAR VOLUMES

Prevalent expression of fibroblast growt

Prevalent expression of fibroblast growth factor (FGF) receptors and FGF2 in human tumor cell lines

✍ Lois A. Chandler; Barbara A. Sosnowski; Lydia Greenlees; Sharon L. Aukerman; And 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 86 KB 👁 2 views

EFFECT OF FGF-1 AND FGF-2 ON VEGF BINDIN

EFFECT OF FGF-1 AND FGF-2 ON VEGF BINDING TO HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

✍ Jun-Hui Chen; Xin-Chang Wang; Mikio Kan; J.Denry Sato 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 89 KB

When FGF-1 or FGF-2 and VEGF were added together, the mitogenic effect of FGF-1 or FGF-2 and VEGF on HUVEC was additive. However, when HUVECs were preincubated for 2 days with 10 ng/ml FGF-1 in the absence of VEGF, the Scatchard plot of [125I]VEGF binding sites was shifted to the right: both affinit

Expression of fibroblast growth factor-1

Expression of fibroblast growth factor-1 (FGF-1), FGF-2 and FGF receptor-1 in a human salivary-gland adenocarcinoma cell line: Evidence of autocrine growth

✍ Yoshiko Myoken; Yoshinari Myoken; Tetsuji Okamoto; Mikio Kan; Wallace L. McKeeha 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 956 KB

Regulation of FGF-2 by an endogenous ant

Regulation of FGF-2 by an endogenous antisense RNA: Effects on cell adhesion and cell-cycle progression

✍ Leigh-Ann MacFarlane; Paul R. Murphy 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB

## Abstract Fibroblast growth factor (FGF‐2) and its endogenous antisense RNA FGF antisense (FGF‐AS) have been implicated in cancer progression and correlated with clinical outcomes of cancer patients. We previously reported that elevated FGF‐AS expression is associated with reduced tumor recurrenc

Constitutive expression of FGF2/bFGF in

Constitutive expression of FGF2/bFGF in non-tumorigenic human prostatic epithelial cells results in the acquisition of a partial neoplastic phenotype

✍ Frédéric Ropiquet; Philippe Berthon; Jean-Marie Villette; Gaëlle Le Brun; Norman 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 119 KB 👁 1 views

Antisense oligodeoxynucleotide against H

Antisense oligodeoxynucleotide against HST-1/FGF-4 suppresses tumorigenicity of an orthotopic model for human germ cell tumor in nude mice

✍ Kotaro Hirai; Hideo Sasaki; Hiromi Sakamoto; Fumitaka Takeshita; Koji Asano; Yos 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 143 KB

## Abstract ## Background Overexpression of the fibroblast growth factor __HST‐1/FGF‐4__ gene is thought to mediate growth properties and malignancy in human testicular germ cell tumors. We have studied the effect that an antisense oligodeoxynucleotide against HST‐1/FGF‐4 suppresses tumorigenicity