✦ LIBER ✦

EFFECT OF FGF-1 AND FGF-2 ON VEGF BINDING TO HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS

✍ Scribed by Jun-Hui Chen; Xin-Chang Wang; Mikio Kan; J.Denry Sato

Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 89 KB
Volume: 25
Category: Article
ISSN: 1065-6995
DOI: 10.1006/cbir.2000.0617

No coin nor oath required. For personal study only.

✦ Synopsis

When FGF-1 or FGF-2 and VEGF were added together, the mitogenic effect of FGF-1 or FGF-2 and VEGF on HUVEC was additive. However, when HUVECs were preincubated for 2 days with 10 ng/ml FGF-1 in the absence of VEGF, the Scatchard plot of [125I]VEGF binding sites was shifted to the right: both affinity classes of VEGF binding sites were equally affected, such that the total number of sites increased twofold. It is suggested that this type of interaction may be related to tumor angiogenesis and wound repair.

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