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Tumor versus vascular photodamage in a rat tumor model

✍ Scribed by David Kessel; James Hampton; Victor Fingar; Alan Morgan

Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
314 KB
Volume
45
Category
Article
ISSN
1011-1344

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✦ Synopsis

The [ 4-( 5-nitro-Z-furyl)-Z-tbiazoyl] formamide (FANIT)-induced urotbelial tumor in the rat is found to express the mdr gene. The resulting multidrug resistance (MDR) phenotype results in the expression of an outward transport system that prevents cellular accumulation of certain weakly cationic agents. Among the latter is a photosensitizer with known efficacy for the FANFT tumor, the copper benzochlorin iminium salt. FANFI cells are protected from direct cell kill mediated by this drug, suggesting that the substantial delay in tumor regrowth from this tumor/sensitizer combination can be attributed to vascular effects.

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