## Abstract In this preliminary report, evaluation of nontraditional agents has been used to evaluate control of metastasis. This androgenβsensitive rat prostic adenocarcinoma has been subject to the treatments of heparin, indocin, and castration, as well as combinations of castration, heparin, ind
Combination chemotherapy in a prostate tumor model: Nb rat prostatic adenocarcinoma model
β Scribed by Joseph R. Drago; Thomas Worgul; M. Eric Gershwin
- Publisher
- John Wiley and Sons
- Year
- 1981
- Tongue
- English
- Weight
- 798 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0022-4790
No coin nor oath required. For personal study only.
β¦ Synopsis
Abstract
This report presents the experience with single and combination chemotherapy in the Noble rat prostatic adenocarcinoma model. The best single agent in treatment of these tumors is cyclophosphamide, the best combination was triple drug therapy cyclophosphamide, cisβplatiβnum, and adriamycin. This report examines the effect of the various chemotherapeutic regimens on tumor volume, number of metastasis, and complete tumor regression.
π SIMILAR VOLUMES
Adriamycin used in combination with vitamin E (Tocopherol) was evaluated in the treatment of Nb rat prostate adenocarcinoma. Vitamin E has been shown to enhance the growth-inhibitory effects of adriamycin on human prostatic carcinoma cells in vitro. The adriamycin-vitamin E treatment groups had the
During the course of the last 6 years, this laboratory unit has evaluated the Nb rat prostate adenocarcinoma model with respect to various chemotherapies. Heretofore, tumors were treated after they had been implanted in the subcutaneous space. The most active chemotherapeutic agents have been cyclop