Tumor uptake studies of S-adenosyl-l-[methyl-11C]methionine and l-[methyl-11C]methionine
β Scribed by Ishiwata, Kiichi; Ido, Tatsuo; Abe, Yoshinao; Matsuzawa, Taiju; Iwata, Ren
- Book ID
- 122831802
- Publisher
- Elsevier Science
- Year
- 1988
- Weight
- 392 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0883-2897
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On-line ["Clmethylation using ["Clmethyl iodide has been successfully applied to the preparation of L-[methyl-"Clmethionine ("C-Met). ["C]Methyl iodide is first trapped in a short column that contains Porapak Q and L-homocysteine thiolactone coated on inert support. The column is then charged with N
Four patients with radiologically normal pituitary gland were examined with positron emission tomography after the administration of (meth-ylJ1C)-L-methionine. On a following day the examination was repeated with (methyl-lOC)-D-methionine. The accumulation rate of L-methionine in the pituitary was m
The routine measurement of L-[methyl-11C]methionine in human plasma after i.v. injection of the tracer is described. The protein-free plasma metabolites of the tracer were analyzed using a cation-exchange column (Aminex A-6) eluted with a pH 4.25 citrate buffer. The ratios of L-[methyl-11C]methionin