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Tumor suppressor p53 induces miR-1915 processing to inhibit Bcl-2 in the apoptotic response to DNA damage

✍ Scribed by Nakazawa, Kazuya; Dashzeveg, Nurmaa; Yoshida, Kiyotsugu

Book ID
121817389
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
377 KB
Volume
281
Category
Article
ISSN
1432-1327

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Background. In many tumors, the p53 gene has been mutated or deleted. p53 null mutant mice are prone to development of a variety of neoplasms at an early age. In head and neck cancer, p53 mutations are detected in most cases. p53 has been shown to induce growth arrest, differentiation, and death whe