Tumor suppressor functions for the Cdk inhibitor p21 in the mouse colon
โ Scribed by Poole, Aleksandra Jovanovic; Heap, Darien; Carroll, Robert E; Tyner, Angela L
- Book ID
- 110069061
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 339 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
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๐ SIMILAR VOLUMES
## Abstract The present study was undertaken to investigate the regulation of P12^CDK2AP1^ by miRNAs. A conserved target site for miRโ21 within the __CDK2AP1__โ3โฒโUTR at nt 349โ370 was predicted by bioinformatics software and an inverse correlation of miRโ21 and __CDK2AP1__ protein was observed. Hi
p63 and p73 are functionally and structurally related to the tumor suppressor p53. However, their own role in tumor suppression is unclear. Given the p53-like properties of p63 and p73, we tested whether they are involved in tumor suppression by aging mice heterozygous for mutations in all p53 famil