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Tumor suppression by Ink4a–Arf: progress and puzzles

✍ Scribed by Scott W Lowe; Charles J Sherr

Book ID
117654851
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
138 KB
Volume
13
Category
Article
ISSN
0959-437X

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Tumor suppression by Ink4a–Arf: progress
Tumor suppression by Ink4a–Arf: progress and puzzles
✍ Scott W Lowe; Charles J Sherr 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 138 KB

The two products of the Ink4a±Arf locus, p16 Ink4a and p19 Arf (p14 ARF in humans), are potent tumor suppressors that regulate the activities of the retinoblastoma protein and the p53 transcription factor. These proteins form part of a signaling network that is disrupted in most, if not all, cancer