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Suppression of mouse colon tumor angiogenesis by the INK4a/ARF locus

✍ Scribed by Dai, Charlotte Y.; Steven L., Gibson; Gee, Michael S.; Lee, William Mf; Lee, Han-Woong; Depinho, Ronald A.; Enders, Greg H.


Book ID
124112574
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
179 KB
Volume
120
Category
Article
ISSN
0016-5085

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Tumor suppression by Ink4a–Arf: progress
✍ Scott W Lowe; Charles J Sherr πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 138 KB

The two products of the Ink4aΒ±Arf locus, p16 Ink4a and p19 Arf (p14 ARF in humans), are potent tumor suppressors that regulate the activities of the retinoblastoma protein and the p53 transcription factor. These proteins form part of a signaling network that is disrupted in most, if not all, cancer