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Tumor reduction in vivo after adenoviral mediated gene transfer of the herpes simplex virus thymidine kinase gene and ganciclovir treatment in human head and neck squamous cell carcinoma

✍ Scribed by ERIC A. GOEBEL; BEVERLY L. DAVIDSON; SCOTT M. GRAHAM; JEFFREY A. KERN


Book ID
117403189
Publisher
SAGE Publications
Year
1998
Tongue
English
Weight
52 KB
Volume
119
Category
Article
ISSN
0194-5998

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We have analyzed the ability of a recombinant replication-defective adenovirus to transfer the thymidine kinase gene of herpes simplex virus (HSV-tk) into hepatocellular carcinoma (HCC) cells to confer sensitivity to ganciclovir. Three HCC cell lines (Hep3B, PLC/PRF/5, and HepG2) were efficiently in