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Tumor proliferation, p53 expression, and apoptosis in laryngeal carcinoma : Relation to the results of radiotherapy

✍ Scribed by Jose Lera; Pedro C. Lara; Sofia Perez; Juan L. Cabrera; Carlos Santana

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 133 KB
Volume: 83
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19981215)83:12<2493::aid-cncr13>3.0.co;2-c

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

Radiotherapy is used in the treatment of laryngeal carcinoma. The search for biologic parameters that could be used to identify patients who will respond to radiotherapy is crucial. The aim of this study was to determine whether the Ki-67 and p53 indices and the pretreatment apoptotic index would be useful in predicting local control and survival for a group of laryngeal carcinoma patients given postoperative radiotherapy.

METHODS.

Fifty-seven patients with laryngeal carcinoma treated between 1988 and 1993 were included in this study. Postoperative radiotherapy was given to a mean dose of 57.7 gray (Gy) (range, 50 -68; median, 60) in 2-Gy daily fractions. Ki-67 and p53 immunostaining were performed on paraffin-embedded tissue. Cells were evaluated for apoptosis using hematoxylin and eosin-stained slides. Clinicopathologic tumor characteristics were studied in relation to Ki-67, p53, and apoptotic indices, and as prognostic factors for local control and survival in both univariate and multivariate analysis.

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