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Tumor penetration and epidermal growth factor receptor saturation by panitumumab correlate with antitumor activity in a preclinical model of human cancer

✍ Scribed by Daniel J Freeman, Kevin McDorman, Selam Ogbagabriel, Carl Kozlosky, Bing-Bing Yang, Sameer Doshi, Juan Jose Perez-Ruxio, William Fanslow, Charlie Starnes, Robert Radinsky

Book ID: 119901845
Publisher: BioMed Central
Year: 2012
Tongue: English
Weight: 556 KB
Volume: 11
Category: Article
ISSN: 1476-4598
DOI: 10.1186/1476-4598-11-47

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## Abstract The proteasome plays a pivotal role in the turnover of regulatory transduction proteins induced by activated cell membrane growth factor receptors. The epidermal growth factor receptor (EGFR) pathway is crucial in the development and progression of human epithelial cancers. Proteasome i