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286 Generation of a recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) with an antitumor activity in a variety of human cancer xenograft models

✍ Scribed by I. Goetsch; A. Gonzalez; A. Beck; J.F. Haeuw; N. Corvaia


Book ID
118621469
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
288 KB
Volume
2
Category
Article
ISSN
1359-6349

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## Abstract Interaction of insulin‐like growth factor receptor I (IGF‐IR) with its ligands has been reported to induce cell proliferation, transformation and blockade of cell apoptotic functions. IGF‐IR is overexpressed on numerous tumor cell types and its blockade could be of importance for anti‐c

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