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Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor

✍ Scribed by Chen, C.; Zhang, Y.; Zhang, Y.; Li, J.; Tsao, S. W.; Zhang, M.-Y.


Book ID
126275577
Publisher
American Association for Cancer Research
Year
2013
Tongue
English
Weight
767 KB
Volume
13
Category
Article
ISSN
1535-7163

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## Abstract Interaction of insulin‐like growth factor receptor I (IGF‐IR) with its ligands has been reported to induce cell proliferation, transformation and blockade of cell apoptotic functions. IGF‐IR is overexpressed on numerous tumor cell types and its blockade could be of importance for anti‐c