Tumor necrosis factor-α promoter polymorphism is associated with the risk of Parkinson's disease

✍ Scribed by Yih-Ru Wu; I-Hsin Feng; Rong-Kuo Lyu; Kuo-Hsuan Chang; Yu-Yun Lin; Huiling Chan; Fen-Ju Hu; Guey-Jen Lee-Chen; Chiung-Mei Chen

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 73 KB
• Volume: 144B
• Category: Article
• ISSN: 1552-4841
• DOI: 10.1002/ajmg.b.30435

✦ Synopsis

Abstract

Inflammatory events may contribute to the pathogenesis of Parkinson's disease (PD). We conducted a case‐control study in a cohort of 369 PD cases and another cohort of 326 ethnically matched controls to investigate the association of tumor necrosis factor‐α (TNF‐α) promoter single nucleotide polymorphisms (SNPs) with the risk of PD. The overall genotype distribution at T‐1031C and C‐857T sites showed significant difference between PD cases and controls (P = 0.0062 and 0.0035, respectively). However, only the more frequent −1031 CC genotype was evidently associated with PD (P = 0.0085, odds ratio: 2.96; 95% CI: 1.38–7.09). Pairwise SNP linkage disequilibrium showed −1031 and −863 sites are in strong linkage disequilibrium (D′ = 0.93, Δ^2^ = 0.80). Pairwise haplotype analysis among the four sites showed that −1031C‐863A may act as a risk haplotype among PD cases (P = 0.0028, odds ratio: 2.18; 95% CI: 1.33–3.69). © 2006 Wiley‐Liss, Inc.