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Tumor necrosis factor α production by peripheral blood mononuclear cells of patients with chronic liver disease

✍ Scribed by Kentaro Yoshioka; Shinichi Kakumu; Motohiro Arao; Yasuhiko Tsutsumi; Masaki Inoue

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
529 KB
Volume
10
Category
Article
ISSN
0270-9139

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✦ Synopsis

We investigated the production of tumor necrosis factor a by peripheral blood mononuclear cells of patients with chronic liver disease and its association with hepatitis activity. Tumor necrosis factor a production was measured with an enzyme-linked immunosorbent assay. Tumor necrosis factor a production by peripheral blood mononuclear cells stimulated with recombinant y-interferon of patients with chronic active hepatitis (5.8 f 4.0 units per ml, p < 0.05) and patients with cirrhosis (4.1 f 2.1 units per ml, p < 0.05) was significantly increased when compared with controls (2.5 f 1.6 units per ml).

Tumor necrosis factor a production by peripheral blood mononuclear cells stimulated with a combination of recombinant y-interferon and recombinant interleukin 2 of patients with chronic persistent hepatitis (5.8 f 3.8 units per ml, p < 0.05), patients with chronic active hepatitis (8.9 f 3.0 units per ml, p < 0.001) and patients with cirrhosis (6.7 f 3.2 units per ml, p < 0.05) was

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