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Enhanced Production Of Interleukin-1 And Tumor Necrosis Factor α By Cultured Peripheral Blood Monocytes From Patients With Scleroderma

✍ Scribed by Hisanori Umehara; Shunichi Kumagai; Masao Murakami; Toshihiko Suginoshita; Koichiro Tanaka; Seiichi Hashida; Eiji Ishikawa; Hiroo Imura

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
376 KB
Volume
33
Category
Article
ISSN
0004-3591

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✦ Synopsis

Cultured peripheral blood mononuclear cells from 20 patients with scleroderma were shown to produce high levels of interleukin-la, interleukin-lp, and tumor necrosis factor a. There were positive correlations between the production of these 3 molecules. Purified monocytes from these patients produced much more tumor necrosis factor a than did those from normal subjects, even without lipopolysaccharide stimulation. These results show the hyperactivity of monocytes from scleroderma patients.

Diffuse or perivascular cellular infiltration is often observed in either the dermis or the subcutaneous tissues of patients with scleroderma (systemic sclerosis; SSc). These infiltrates have been shown to predominantly consist of either T lymphocytes or both .

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