Tumor Necrosis Factor α Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts
✍ Scribed by Lee, Angela; Qiao, Yu; Grigoriev, Galina; Chen, Janice; Park-Min, Kyung-Hyun; Park, Sung Ho; Ivashkiv, Lionel B.; Kalliolias, George D.
- Book ID
- 120308556
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 461 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0004-3591
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📜 SIMILAR VOLUMES
Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor a (TNFa). Seven of 12 sera from RA patients contained TNFa, while only 1 of those from reactive arthritis patients was positive.
## Abstract ## Objective To investigate the roles of MAPKs and NF‐κB in tumor necrosis factor α (TNFα)–induced expression of vascular cell adhesion molecule 1 (VCAM‐1) in human rheumatoid arthritis synovial fibroblasts (RASFs). ## Methods Human RASFs were isolated from synovial tissue obtained f