Tumor necrosis factor α haplotypes versus tumor necrosis factor α −308 G/A polymorphism in the prediction of infliximab treatment efficacy in rheumatoid arthritis
✍ Scribed by Bénédicte Mugnier; Jean Roudier
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 112 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0004-3591
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📜 SIMILAR VOLUMES
## Abstract ## Objective To test whether the G‐to‐A polymorphism at position −308 in the promoter of the tumor necrosis factor α (TNFα) gene influences response to infliximab therapy in patients with rheumatoid arthritis (RA). ## Methods We genotyped 59 RA patients by polymerase chain reaction a
Synovial fluids from 6 of 12 patients with rheumatoid arthritis (RA) and from 3 of 11 patients with reactive arthritis contained measurable levels of tumor necrosis factor a (TNFa). Seven of 12 sera from RA patients contained TNFa, while only 1 of those from reactive arthritis patients was positive.
## Abstract ## Objective Infliximab, an anti–tumor necrosis factor α (anti‐TNFα) antibody, is effective in the treatment of several immunoinflammatory diseases. However, many patients experience primary or secondary response failure, suggesting that individualization of treatment regimens may be b
The authors are the principal investigators of the British Society of Rheumatology (BSR) Biologics Register. The BSR receives financial support for the Register from the manufacturers of biologic agents currently licensed for use in the treatment of patients with inflammatory rheumatic diseases. The