Tumor necrosis factor α and insulin resistance in obese type 2 diabetic patients
✍ Scribed by Miyazaki, Y; Pipek, R; Mandarino, L J; DeFronzo, Ralph A.
- Book ID
- 110045083
- Publisher
- Nature Publishing Group
- Year
- 2003
- Tongue
- English
- Weight
- 131 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1476-5497
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Tumor necrosis factor alpha-converting enzyme (TACE, also known as ADAM17) was recently involved in the pathogenesis of insulin resistance. We observed that TACE activity was significantly higher in livers of mice fed a high-fat diet (HFD) for 1 month, and this activity was increased in liver > whit
## Abstract Data from the health survey for England 2006 1, showed that the prevalence of type 2 diabetes mellitus (T2DM) has more than doubled in men and women since 1991. In the USA certain States have a prevalence of T2DM of greater than 10% 2. Globally it has been reported that this increase is