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Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus

โœ Scribed by Michelle C. Venables; Asker E. Jeukendrup

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
456 KB
Volume
25
Category
Article
ISSN
1520-7552

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โœฆ Synopsis

Abstract

Data from the health survey for England 2006 1, showed that the prevalence of type 2 diabetes mellitus (T2DM) has more than doubled in men and women since 1991. In the USA certain States have a prevalence of T2DM of greater than 10% 2. Globally it has been reported that this increase is by no means slowing down and that the number of individuals with the disease is expected to rise from 171 million cases reported in 2000 to 366 million by the year 2030 3. Physical inactivity and obesity are two major risk factors for the development of T2DM. In this review we will discuss evidence of an association between physical inactivity, obesity and T2DM from prospective cohort studies and clinical trials. We will also discuss some of the potential mechanisms that are thought to link obesity and physical inactivity with the major pathophysiological precursor of T2DM, insulin resistance. Copyright ยฉ 2009 John Wiley & Sons, Ltd.

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Relationships Between Plasma Leptin and Insulin Concentrations, But Not Insulin Resistance, in Non-insulin-Dependent (Type 2) Diabetes Mellitus
โœ Mohamed-Ali, V.; Pinkney, J.H.; Panahloo, A.; Goodrick, S; Coppack, S.W.; Yudkin ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 124 KB ๐Ÿ‘ 2 views

In non-diabetic subjects, insulin concentrations and insulin resistance are clearly connected, and both correlate with leptin levels, making interpretations about mechanisms difficult. In non-insulin-dependent (Type 2) diabetes mellitus (NIDDM), however, insulin concentrations and insulin resistance