Tumor necrosis factor alpha induces senescence and chromosomal instability in human leukemic cells
✍ Scribed by Beyne-Rauzy, Odile; Recher, Christian; Dastugue, Nicole; Demur, Cécile; Pottier, Géraldine; Laurent, Guy; Sabatier, Laure; Mansat-De Mas, Véronique
- Book ID
- 110069091
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 291 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0950-9232
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The present study examined differentiation-inducing activity by various tumor-necrosis-factor(TNF) mutants against the human leukemic cell lines HL-60 and U-937. Mutant TNF 471, from which 7 N-terminal amino acids of native TNF were deleted and Pro 8 , Ser 9 and Asp 10 were replaced by Arg, Lys and
## Abstract It has been reported that expression of tumor necrosis factor superfamily members occur at the onset of the mammary gland post‐lactational involution. One of these proteins, tumor necrosis factor alpha (TNFα), is a major mediator of inflammation that is able to induce expression of seve