✦ LIBER ✦

Tumor lymphangiogenesis in head and neck squamous cell carcinoma : A morphometric study with clinical correlations

✍ Scribed by Alessandro Franchi; Oreste Gallo; Daniela Massi; Gianna Baroni; Marco Santucci

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 159 KB
Volume: 101
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.20454

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

BACKGROUND

Tumor metastasis to regional lymph nodes via the lymphatic system represents the first step of dissemination in head and neck squamous cell carcinoma (HNSCC) and serves as a major prognostic indicator for disease progression and as a guide for therapeutic strategies. In the current study, the authors investigated whether tumor lymphangiogenesis may be related to the risk of lymph node metastasis and to clinical outcome in patients with HNSCC.

METHODS

Immunostaining for the lymphatic marker D2‐40 was used, and lymphangiogenesis was quantified within the tumor and in the peritumoral area in 52 HNSCC specimens using computer‐assisted morphometric analysis.

RESULTS

Lymphatic vessels were found to be significantly more numerous and larger in the peritumoral area compared with within the tumor, and the number and relative area of intratumoral and peritumoral lymphatics was significantly higher in HNSCC cases with lymph node metastasis. Multivariate analysis demonstrated that high peritumoral lymphangiogenesis (above the median value) was associated with an increased risk of developing lymph node metastasis. No correlation was found between tumor lymphangiogenesis and the disease‐free or overall survival in the current series.

CONCLUSIONS

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