Tumor localization of Lewis lung carcinoma with radiolabeled monoclonal antibodies
✍ Scribed by Patrick Midoux; Thierry Maillet; Fabienne Thérain; Michel Monsigny; Annie Claude Roche
- Publisher
- Springer-Verlag
- Year
- 1984
- Tongue
- English
- Weight
- 801 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0340-7004
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## Abstract Lewis lung carcinoma (3LL) is a spontaneous murine lung carcinoma which preferentially metastasizes into the lung. Monoclonal antibodies (MAb) against 3LL cells were prepared by fusing spleen cells from rats immunized with 3LL and the P3‐NSI/I‐Ag4 (NSI) plasmacytoma. Two hybridomas were
Nude mice carrying human squamous-cell carcinoma xenografts were given i.v. injections of radiolabelled monoclonal antibodies (Mas). MAb E 48, which reacts with squamouscell carcinomas, was labelled with i3'l, while a second control MAb of similar immunoglobulin subclass was labelled with lZ5l. Both