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Tumor heterogeneity in ovarian cancer as demonstrated by in vitro chemoresistance assays

โœ Scribed by J.N. McAlpine; S.M. Eisenkop; N.M. Spirtos


Book ID
113961643
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
290 KB
Volume
110
Category
Article
ISSN
0090-8258

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We have designed an in vitro assay to assess the influence of tumor subpopulation interactions on drug response. The assay is based upon inhibition of growth of 1 mm3-pieces of tumor embedded in a collagen gel matrix. Tumor growth is quantitated by planimetry of each colony's image, formed with a sp