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Tumor-derived TGF-β reduces the efficacy of dendritic cell-tumor fusion vaccine against colon cancer

✍ Scribed by John Y. Kao; Yusong Gong; Chuan-Min Chen; Quiong-Duan Zheng; Jian-Jun Chen

Book ID: 119391332
Publisher: Nature Publishing Group
Year: 2001
Tongue: English
Weight: 39 KB
Volume: 96
Category: Article
ISSN: 0002-9270
DOI: 10.1016/s0002-9270(01)03222-1

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## Abstract Cyclooxygenase‐2 (COX‐2) is a rate‐limiting enzyme in the synthesis of prostaglandins. It is over‐expressed in multiple cancers and has been associated with diminished tumor immunity. Dendritic cells (DCs) are considered candidates for cancer immunotherapy due to their ability to proces